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Covid ‘Sudden Deaths’ Have Not Increased Due To Vaccines: ICMR Study

Jul 7, 2025 | Pratirodh Bureau

The study showed that Covid vaccination was not responsible for sudden and unexplained deaths seen among young and healthy individuals

A recent study led by the Indian Council of Medical Research (ICMR) has shed light on the factors contributing to unexplained sudden deaths among young adults in India, particularly those aged 18-45 years. Published in the peer-reviewed Indian Journal of Medical Research, the study addresses concerns that have arisen following anecdotal reports linking sudden deaths in apparently healthy individuals to Covid-19 infection or vaccination.

The researchers emphasized that “Covid-19 vaccination did not increase the risk of unexplained sudden death among young adults in India.” This finding is significant, especially in the context of widespread concerns regarding the safety of vaccines. The study indicates that, rather than being a cause of sudden deaths, vaccination may actually play a protective role. The researchers noted, “The results showed that receiving at least one dose of Covid-19 vaccine lowered the odds for unexplained sudden death,” and further clarified that “two doses, further, lowered the odds of unexplained sudden death.”

The study was conducted in 2023, following a period marked by reports of sudden, unexplained deaths among young adults who were otherwise healthy. The researchers sought to investigate the underlying factors contributing to these tragic events. They utilized a multicentric matched case-control model, which included 729 cases of sudden unexplained deaths and 2,916 controls from 47 tertiary care hospitals across India. The cases involved individuals who appeared healthy just 24 hours before their sudden deaths and had no known co-morbidities.

In their methodology, the team matched four controls per case based on age, gender, and neighborhood, ensuring a robust comparison. Data collection involved interviews and record reviews, focusing on various factors such as Covid vaccination status, history of Covid-19 infection, family history of sudden death, and lifestyle behaviors. The researchers specifically looked into smoking habits, recreational drug use, alcohol consumption frequency, binge drinking, and vigorous-intensity physical activity performed within two days prior to death or interviews.

The findings revealed that certain lifestyle behaviors were positively associated with an increased risk of unexplained sudden death. The researchers pointed out that “past Covid-19 hospitalisation, family history of sudden death, binge drinking 48 hours before death, use of recreational drug or substance, and performing vigorous-intensity physical activity 48 hours before death were positively associated.” This highlights the multifactorial nature of sudden unexplained deaths, suggesting that a combination of health history and lifestyle choices may contribute to these tragic outcomes.

The study’s results are particularly relevant in the context of ongoing public health discussions surrounding Covid-19 and its long-term effects. By clarifying that vaccination does not contribute to the risk of sudden death, the researchers aim to alleviate concerns among the public and encourage vaccination as a protective measure.

The ICMR study provides critical insights into the factors associated with unexplained sudden deaths among young adults in India. It underscores the importance of considering both medical history and lifestyle factors in understanding these occurrences. As the researchers stated, “Covid-19 vaccination did not increase the risk of unexplained sudden death,” reinforcing the need for continued public health education and awareness regarding the benefits of vaccination and healthy lifestyle choices.

Tags: Covid-19 infection impact, COVID-19 vaccination, health risks Covid-19, ICMR study, lifestyle factors sudden death, peer-reviewed research, Pratirodh, protective role vaccination, public health education, unexplained sudden deaths, young adults India

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